The lab has developed improved methods for studying DNA repair pathways in human cells. These approaches allow researchers to track how cells respond to DNA damage and identify key factors involved in maintaining genome integrity. The work addresses long-standing challenges in measuring repair activity at high resolution.

By combining molecular assays with genomic analysis, the team mapped repair events across different genomic contexts. This revealed variation in repair efficiency depending on chromatin state and DNA sequence features. The findings provide insight into how repair pathways are coordinated with other cellular processes.

Understanding these mechanisms is critical for explaining how genome instability arises in disease. The lab is using these methods to investigate repair defects linked to cancer and inherited disorders.